The determining influence on Luigi Garzi's style occurred at age fifteen, when he entered the Roman workshop of Andrea Sacchi. Sacchi was the chief representative of Roman Baroque painting's classicizing strain, which had originated with Alessandro Algardi and Nicolas Poussin. Garzi's classical training remained the core of his style throughout his career. His early works also display the impact of Bolognese painter Guido Reni's art.
Garzi painted easel pictures, but he is best known for his monumental works. His fresco decorations can be seen in a number of churches in Rome and Naples. While always retaining his commitment to classicism, Garzi modified his style throughout his career in response to the prominent masters of the day, reflecting the influence of Luca Giordano and Francesco Solimena in about 1697 and his awareness of Carlo Maratta's late Baroque manner in the early 1710s. Garzi joined Rome's Accademia di San Luca in 1670 and became its president in 1682, indicating the high level of esteem in which his contemporaries held him.