Lippo Vanni worked in and around Siena as a manuscript illuminator as well as a fresco and panel painter. The commissions he received after the mid-1300s indicate that patrons thought of him as one of the leading painters of his day. In 1356, a record of the painters working in Siena lists Vanni's name first.
Vanni illuminated choir books for the church in San Gimignano and a hospital in Siena. He also painted frescoes in the Palazzo Pubblico in Siena and a hermitage outside Siena. Narrative scenes with elegant, elaborate architectural settings and an adventurous color palette, including deep burgundy and purple, characterize his style.