Malvasia, a seventeenth-century biographer of Bolognese painters, described Nosadella as primarily a fresco painter, but his frescoes have all been lost. The painting in the Getty Museum shows the strident colors, contorted poses, and compressed space characteristic of the advanced form of Roman Mannerism that Nosadella's teacher Pellegrino Tibaldi introduced in Bologna. Nosadella's style is characterized by heavy, angular drapery; female figures with long, broad noses; and hands with index and middle fingers that form a V.
Only two altarpieces in Bologna are securely connected with this artist. His altarpiece at Santa Maria della Vita is related to the colorful style of Florentine Andrea del Sarto. The altarpiece at Santa Maria Maggiore was finished by another artist after Nosadella's death. In addition to altarpieces, Nosadella also painted mythological and historical scenes.